BDBM4304 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide::CHEMBL56731::cid_5328771::tyrphostin 1
SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O
InChI Key InChIKey=HKHOVJYOELRGMV-XYOKQWHBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 4304
Affinity DataIC50: 700nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair